Milroy's disease: your comprehensive guide

A genetic disorder called Milroy disease impairs the lower extremities' lymphatic system's ability to function. Continue reading the following article to learn more about the causes, symptoms and treatment methods for Milory disease.

Milroy's disease: your comprehensive guide

What is Milroy disease, also known as congenital familial lymphedema, which affects the lymphatic system and causes a person to be born with a number of symptoms that may have an impact on his daily life?

Milroy's disease

The symptoms of Milroy's disease can be seen in the foetus before birth or soon after birth. It is one of the uncommon genetic diseases that results in a defect in the body's lymphatic system function.

Although the cause of Milroy disease is unknown, some individuals may be affected by a genetic mutation that affects the production of specific proteins necessary for the growth and development of the cells that make up the lymphatic vessels in the body. This results in the non-formation of lymphatic vessels or the formation of narrow lymphatic vessels that obstruct the normal drainage of lymphatic fluid.

Symptoms of Milroy's disease

People with Milroy disease suffer from a number of side effects that differ and range in severity from one person to another. The Milroy disease's most noticeable side effects are listed below:

  • Lymphedema is a condition in which lymph fluid builds up in one or both lower extremities, particularly the ankles, giving them a swollen appearance from birth.
  • Infected males have abnormalities in the development of the urinary tract and lymph fluid around the testicles.
  • the patient's lower extremities are repeatedly exposed to cellulitis, which worsens lymphatic vessel damage and increases foot swelling.
  • the swollen lower extremities' clearly visible and prominent vein appearance.
  • In addition to the development of wart-like skin growths on the feet and around the fingers, hyperkeratosis causes the skin on the lower extremities to change in nature as a result of its ongoing swelling, making it thicker and rougher.
  • a condition in which a person is born with toenail deformities that cause them to point upwards.
  • Some patients struggle with learning issues and behavioural disorders.
  • increase the likelihood that the patient will develop cancer, especially skin tumours and angiosarcoma.

How is Milroy's disease diagnosed?

The following diagnostic techniques are a few that the doctor uses to identify Milroy's disease:

  1. Complete physical examination and knowledge of the side effects that the patient suffers from.
  2. Know the medical history of the patient and his family.
  3. Lymphoscintigraphy to detect abnormalities in the functioning of the lymphatic system .
  4. Performing a number of other imaging tests, such as: Doppler ultrasound, magnetic resonance imaging, and tomography.

A genetic test may occasionally be used by a physician to confirm a Milroy disease diagnosis.

Milroy's disease treatment

Treatment in the case of Milroy disease depends on controlling the symptoms associated with the disease, so as to reduce their impact on the patient’s daily life. The most well-known of these treatment options are those we mention below:

  • utilising special bandages or corsets to reduce swelling in the lower extremities, as well as receiving a therapeutic massage to promote lymphatic drainage.
  • Vascularized lymph node transfer, also known as VLNT, is the movement of healthy lymphatic vessels from one area of the body to another in order to lessen swelling and enhance lymphatic drainage.
  • Treatment of congenital defects that may affect the extremities, including warts and skin growths, as well as defects of the reproductive and urinary systems in some infected males.
  • treatment of skin tissue inflammation with doctor-prescribed antibiotics as soon as possible.

Advice for patients with Milroy's disease

The patient is advised to avoid exposing the lower extremities to any kind of wounds or infections due to the weak ability of the body to resist infection in the affected extremities. Additionally, it is advised to continuously keep the lower extremities clean, maintain a healthy weight, and refrain from taking any medications that might make them swell more.

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